Exposé de Karim Benchenane dans le cadre du colloquim du Département d'Etudes Cognitives
From necessity to sufficiency in memory research: when sleep helps to understand wake experiences
Memory is the ability to adapt our behavior by using the stored information, previously encoded. The first investigations of the neuronal bases of the memory trace concerned its properties (location, cellular and molecular mechanisms, among others). However, to understand how this is achieved at the scale of neurons, we must provide evidence about the necessity of a neuronal subpopulation to support the memory trace, but also its sufficiency. Here, we will present past and recent studies that provide information about the neuronal nature of memories. We will show that research on sleep, when cells assembly supposedly carrying information from the past are replayed, could also provide valuable information about the memory processes at stake during wake.
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Karim Benchenane est chercheur CNRS, responsable de l’équipe “Memory, Oscillations and Brain states” au sein de l’unité Plasticité du Cerveau à l’ESPCI-ParisTech. Ses recherches concernent l’influence des différents états de vigilance et des oscillations cérébrales dans le traitement des informations et leurs mémorisations. S’intéressant tout particulièrement au rôle du sommeil dans la consolidation de la mémoire, il utilise pour cela des enregistrements électrophysiologiques extracellulaires sur des rongeurs.
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